Structure of PDB 6sk9 Chain A

Receptor sequence
>6sk9A (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
RAEDYEVLYTIGTRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVN
LLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQY
LDEEFVLRVMTQLTLALKECHRRLKPANVFLDGKQNVKLGDFGTPYYMSP
EQMNNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYR
YSDELNEIITRMLNLKDYHRPSVEEILENPLILEHHHHHH
3D structure
PDB6sk9 Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K143 A145 N146 D159 T179
Catalytic site (residue number reindexed from 1) K125 A127 N128 D141 T144
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F9N A G15 T16 C22 M86 E87 Y88 C89 G92 D93 F148 G12 T13 C15 M79 E80 Y81 C82 G85 D86 F130 MOAD: ic50=1.42uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6sk9, PDBe:6sk9, PDBj:6sk9
PDBsum6sk9
PubMed32242624
UniProtP51955|NEK2_HUMAN Serine/threonine-protein kinase Nek2 (Gene Name=NEK2)

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