Structure of PDB 6sjv Chain A

Receptor sequence
>6sjvA (length=529) Species: 9606,333761 [Search protein sequence]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSAVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDAALAAAQTNAAAMARFEDPTRRPYKLPDLCTELNTSLQDIEI
TCVYCKTVLELTEVFEFARKDLFVVYRDSIPHAACHKCIDFYSRIRELRH
YSDSVYGDTLEKLTNTGLYNLLIRCLRCQKPLNPAEKLRHLNEKRRFHNI
AGHYRGQCHSCCNAESSELTFQELLGERR
3D structure
PDB6sjv Cellular target recognition by HPV18 and HPV49 oncoproteins
ChainA
Resolution2.029 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A D15 K16 E112 W231 D14 K15 E111 W230
BS02 GLC A W63 D66 R67 E154 P155 Y156 W341 W62 D65 R66 E153 P154 Y155 W340
BS03 ZN A C1105 C1108 C1138 C1141 C475 C478 C508 C511
BS04 ZN A C1032 C1035 C1065 C1068 C402 C405 C435 C438
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006355 regulation of DNA-templated transcription
GO:0008643 carbohydrate transport
GO:0019049 virus-mediated perturbation of host defense response
GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway
GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
GO:0039648 symbiont-mediated perturbation of host ubiquitin-like protein modification
GO:0045892 negative regulation of DNA-templated transcription
GO:0052150 symbiont-mediated perturbation of host apoptosis
GO:0055085 transmembrane transport
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6sjv, PDBe:6sjv, PDBj:6sjv
PDBsum6sjv
PubMed
UniProtP06463;
Q05086|UBE3A_HUMAN Ubiquitin-protein ligase E3A (Gene Name=UBE3A)

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