Structure of PDB 6si4 Chain A

Receptor sequence
>6si4A (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLI
RVEGNLRAEYLDDRNTFRHSVVVPSEPPEVGSDCTTIHYNYMCYSSCMGG
MNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRK
3D structure
PDB6si4 Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C176 H179 C238 C242 C81 H84 C143 C147
BS02 LEK A V147 P151 S220 E221 P222 P223 D228 T230 V52 P56 S125 E126 P127 P128 D133 T135 MOAD: Kd=5.9uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6si4, PDBe:6si4, PDBj:6si4
PDBsum6si4
PubMed31990523
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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