Structure of PDB 6si0 Chain A

Receptor sequence
>6si0A (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
SSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQ
LWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHL
IRVEGNLRAEYLDDRNTFRHSVVVPCEPPEVGSDCTTIHYNYMCYSSCMG
GMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRK
3D structure
PDB6si0 Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm.
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C176 H179 C238 C242 C82 H85 C144 C148
BS02 LEK A L145 V147 T150 P151 C220 E221 P222 P223 D228 T230 L51 V53 T56 P57 C126 E127 P128 P129 D134 T136 MOAD: Kd=5.3uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6si0, PDBe:6si0, PDBj:6si0
PDBsum6si0
PubMed31990523
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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