Structure of PDB 6shv Chain A

Receptor sequence
>6shvA (length=351) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
ASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFR
GMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIM
DGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKD
LLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYK
RIVKYKTTFYTYLLPLVMGLLVSEAAASVEMNLVERVAHLIGEYFQVQDD
VMDCFTPPGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGEKDPAKVAV
VKRLYSKANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKT
H
3D structure
PDB6shv Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
ChainA
Resolution1.808 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K48 H93 D98 D102 R107 D170 K207 F246 D250 D251
Catalytic site (residue number reindexed from 1) K47 H92 D97 D101 R106 D169 K206 F245 D249 D250
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LDW A Y94 M101 T163 Q167 Y211 Y93 M100 T162 Q166 Y210
BS02 LDW A L19 D20 Q23 I28 D29 P30 A33 L18 D19 Q22 I27 D28 P29 A32
BS03 ZN A D98 D102 D97 D101
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0008299 isoprenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6shv, PDBe:6shv, PDBj:6shv
PDBsum6shv
PubMed
UniProtQ8WS26

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