Structure of PDB 6sh6 Chain A

Receptor sequence
>6sh6A (length=681) Species: 9606 (Homo sapiens) [Search protein sequence]
PHMLEQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFV
LVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVAD
EMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVI
ILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNC
PLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLT
GQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPK
QNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLV
TAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLG
SVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTEL
GSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKK
AADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSAD
NVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTG
HYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWL
VKIAPQYYDMSNFPQCEAKRQLDRIIAKLQS
3D structure
PDB6sh6 Structural basis for DEAH-helicase activation by G-patch proteins.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A L137 T162 G163 S164 G165 K166 T167 T168 R204 F401 T429 D431 L30 T55 G56 S57 G58 K59 T60 T61 R97 F294 T321 D323
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6sh6, PDBe:6sh6, PDBj:6sh6
PDBsum6sh6
PubMed32179686
UniProtO43143|DHX15_HUMAN ATP-dependent RNA helicase DHX15 (Gene Name=DHX15)

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