Structure of PDB 6sgh Chain A

Receptor sequence
>6sghA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
SRAEDYEVLYTIGTGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSE
VNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKER
QYLDEEFVLRVMTQLTLALKECHRLKPANVFLDGKQNVKLGDYYMSPEQM
NYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYS
DELNEIITRMLNLKDYHRPSVEEILENPLILEHHHHHH
3D structure
PDB6sgh 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) K143 A145 N146 D159
Catalytic site (residue number reindexed from 1) K126 A128 N129 D142
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LCW A I14 C22 V35 E87 Y88 C89 G92 F148 I12 C17 V30 E82 Y83 C84 G87 F131
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6sgh, PDBe:6sgh, PDBj:6sgh
PDBsum6sgh
PubMed33479670
UniProtP51955|NEK2_HUMAN Serine/threonine-protein kinase Nek2 (Gene Name=NEK2)

[Back to BioLiP]