Structure of PDB 6sfr Chain A

Receptor sequence
>6sfrA (length=466) Species: 9606 (Homo sapiens) [Search protein sequence]
GEEQMRLPSADVYRFAEPDSEENIIFEGIPIIKAGTVIKLIERLTYHMYA
DPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQP
LSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIG
TVRGKAMKKWVESITKIIQRKKIARDTFQSSPPTVEWHISRPGHIETFDL
LTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIR
HTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVS
AMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPC
VPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQN
QPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPR
FPKKYSYPLKSPGVRP
3D structure
PDB6sfr BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.
ChainA
Resolution1.917 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LBK A N879 Y884 F890 L901 H905 N303 Y308 F314 L325 H329
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6sfr, PDBe:6sfr, PDBj:6sfr
PDBsum6sfr
PubMed32816843
UniProtQ07889|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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