Structure of PDB 6sem Chain A

Receptor sequence

>6semA (length=519) Species: 32630 (synthetic construct)

AKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGLWRFKENVEDGR
ASIYQSVITNTSKEMSCFSDFPMPEHFPNFLHNSKLLEYFRIFAKKFDLL
KYIQFQTTVLSVKKCPDGQWEIVTESNGKEQSAVFDAVMVCSGHHILPHI
PLQSFPGIERFKGQYFHSRQYKHPEGFEGKRILVIGIGNSASDIAVELSK
KAAQVFISTRHGSWVMSRISDDGYPWDMVFHTRFSSMLRNVLPRTVVKWM
MEQQMNRWFNHENYGLEPQNKYLMKEPVLNDDLPSRLLYGAIKVKSRVKE
LTETSAIFEDGTVEEDIDVIVFATGYTFSFPFLEDSLVKVENNMVSLYKY
MFPPHLEKPTLACIGLIQPLGSIFPTVELQARWVTRVFKGLCTLPSESTM
MADIIKRNEKRIDLFGESQSQILQTNYIDYLDELALEIGAKPDLLSLLLK
DPKLAMKLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALK
ALLKILGLLAVVVAFFFQL

3D structure

• PDB: 6sem Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs.
• Chain: A
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	I8 G9 G11 V12 S13 F31 E32 R33 G39 L40 W41 T60 N61 T62 V110 C146 S147 F337 S377 I378 F379	I7 G8 G10 V11 S12 F30 E31 R32 G38 L39 W40 T59 N60 T61 V109 C141 S142 F332 S372 I373 F374

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Sun Nov 17 02:32:25 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6sem', asym_id = 'A', title = 'Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6sem', asym_id='A', title='Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0004499,0050660,0050661', uniprot = '', pdbid = '6sem', asym_id = 'A'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0004499,0050660,0050661', uniprot='', pdbid='6sem', asym_id='A')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>