Structure of PDB 6sde Chain A

Receptor sequence
>6sdeA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
HVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLKIHCAVKSLNRIEVSQFLT
EGIIMKDFSHPNVLSLLGICLRSSPLVVLPYMKHGDLRNFIRNETHNPTV
KDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARD
MYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMT
RGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRP
SFSELVSRISAIFSTFIG
3D structure
PDB6sde Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
ChainA
Resolution2.49 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D126 R130 N131 D144
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V0L A I1084 V1092 A1108 Y1159 M1160 D1164 R1208 M1211 A1221 D1222 Y1230 I17 V25 A36 Y81 M82 D86 R130 M133 A143 D144 Y152 PDBbind-CN: -logKd/Ki=10.20,Kd=63pM
BindingDB: IC50=2.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6sde, PDBe:6sde, PDBj:6sde
PDBsum6sde
PubMed31531204
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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