Structure of PDB 6sdc Chain A

Receptor sequence
>6sdcA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
HIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDGK
KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP
LVVLPYMKHGDLRNFIRNHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDL
AARNCMLDEKFTVKVADFGLARVMYDKEYYSVAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPD
PLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
3D structure
PDB6sdc Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.
ChainA
Resolution1.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D149 R153 N154 D167
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 88Z A I1084 V1092 A1108 K1110 E1127 M1131 F1134 L1157 Y1159 M1160 K1161 F1200 H1202 M1211 V1220 A1221 D1222 F1223 I33 V41 A55 K57 E74 M78 F81 L104 Y106 M107 K108 F145 H147 M156 V165 A166 D167 F168 BindingDB: IC50=0.400000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6sdc, PDBe:6sdc, PDBj:6sdc
PDBsum6sdc
PubMed31531204
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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