Structure of PDB 6scg Chain A

Receptor sequence
>6scgA (length=406) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
DMLWHKLPKSIYFRRGSLPIALDEVITDGHKRALIVTDRFLFNNGYADQI
TSVLKAAGVETEVFFEVEADPTLSIVRKGAELANSFKPDVIIALGGGSPM
DAAKIMWVMYEHPETHFEELALRFMDIRKRIYKFPKMGVKAKMIAVTTTS
GTGSEVTPFAVVTDDATGQKYPLADYALTPDMAIVDANLVMDMPKSLCAF
GGLDAVTHAMEAYVSVLASEFSDGQALQALKLLKEYLPASYHEGSKNPVA
RERVHSAATIAGIAFANAFLGVCHSMAHKLGSQFHIPHGLANALLICNVI
RYNANPQARRRYAEIADHLGLSAPGDRTAAKIEKLLAWLETLKAELGIPK
SIREAGVQEADFLANVDKLSEDAFDDQCTGANPRYPLISELKQILLDTYY
GRDYVE
3D structure
PDB6scg High-resolution structure of the alcohol dehydrogenase domain of the bifunctional bacterial enzyme AdhE.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.1: alcohol dehydrogenase.
1.2.1.10: acetaldehyde dehydrogenase (acetylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A D487 F489 A518 D519 G545 G546 S547 T597 T598 T601 V610 L646 H727 D38 F40 A69 D70 G96 G97 S98 T148 T149 T152 V161 L197 H278
BS02 FE A D653 H657 H723 H737 D204 H208 H274 H288
Gene Ontology
Molecular Function
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6scg, PDBe:6scg, PDBj:6scg
PDBsum6scg
PubMed32880589
UniProtP0A9Q7|ADHE_ECOLI Bifunctional aldehyde-alcohol dehydrogenase AdhE (Gene Name=adhE)

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