Structure of PDB 6sbo Chain A

Receptor sequence
>6sboA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVHMINWA
KRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTF
LSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLIL
SHIRHMSNKGMEHLYSMKCKNVVPSYDLLLEMLDAHRLH
3D structure
PDB6sbo Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
ChainA
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L5B A M343 T347 L349 A350 D351 E353 W383 L384 F404 M421 I424 G521 L525 V533 V534 P535 L539 M32 T36 L38 A39 D40 E42 W72 L73 F93 M110 I113 G210 L214 V222 V223 P224 L228 BindingDB: IC50=15.0nM,EC50=0.200000nM
External links
PDB RCSB:6sbo, PDBe:6sbo, PDBj:6sbo
PDBsum6sbo
PubMed31721572
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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