Structure of PDB 6sal Chain A

Receptor sequence
>6salA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWE
MWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRM
CRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSED
EIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLHKTHRQSILAK
LPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
3D structure
PDB6sal Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor gamma t (ROR gamma t) Inverse Agonists.
ChainA
Resolution1.61 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L3E A L324 T325 I328 Q329 L353 K354 M358 L483 Q484 A496 A497 F498 Y502 L505 F506 L59 T60 I63 Q64 L88 K89 M93 L218 Q219 A231 A232 F233 Y237 L240 F241 MOAD: ic50=0.264uM
PDBbind-CN: -logKd/Ki=6.58,IC50=0.264uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6sal, PDBe:6sal, PDBj:6sal
PDBsum6sal
PubMed31821760
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

[Back to BioLiP]