Structure of PDB 6s7o Chain A

Receptor sequence
>6s7oA (length=656) Species: 9606 (Homo sapiens) [Search protein sequence]
LRLSYEKQDTLLKLLILSMAAVLSFSTRLFAVLRFESVIHEFDPYFNYRT
TRFLAEEGFYKFHNWFDDRAWYPLGRIIGGTIYPGLMITSAAIYHVLHFF
HITIDIRNVCVFLAPLFSSFTTIVTYHLTKELKDAGAGLLAAAMIAVVPG
YISRSVAGSYDNEGIAIFCMLLTYYMWIKAVKTGSICWAAKCALAYFYMV
SSWGGYVFLINLIPLHVLVLMLTGRFSHRIYVAYCTVYCLGTILSMQISF
VGFQPVLSSEHMAAFGVFGLCQIHAFVDYLRSKLNPQQFEVLFKISPWTG
RFYSLLDPSYAKNNIPIIASVSEHQPTTWSSYYFDLQLLVFMFPVGLYYC
FSNLSDARIFIIMYGVTSMYFSAVMVRLMLVLAPVMCILSGIGVSQVLST
YMKNLDISRKNEVASGMILVMAFFLITYTFHSTWVTSEAYSSPSIVLSAR
IIFDDFREAYYWLRHNTPEDAKVMSWWDYGYQITAMANRTILVDNNTWNN
THISRVGQAMASTEEKAYEIMRELDVSYVLVIFGGLTGYSSDDINKFLWM
VRIGGSTDTGKHIKENDYYTPTGEFRVDREGSPVLLNCLMYKMCYYRFGQ
VYTEAKRPPGFDRVRNAEIGNKDFELDVLEEAYTTEHWLVRIYKVKDLDN
RGLSRT
3D structure
PDB6s7o Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.
ChainA
Resolution3.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.99.18: dolichyl-diphosphooligosaccharide--protein glycotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KZB A V262 F271 V256 F265
BS02 KZB A H133 Y181 W194 H127 Y175 W188
BS03 KZB A F105 F106 F99 F100
BS04 EGY A L20 L23 V28 L14 L17 V22
BS05 EGY A R231 F379 L382 R225 F351 L354
BS06 KZE A F214 N217 R329 F330 F399 R405 L406 F208 N211 R301 F302 F371 R377 L378
BS07 EGY A L103 N114 F118 L97 N108 F112
BS08 EGY A H69 I94 Y204 S207 H63 I88 Y198 S201
Gene Ontology
Molecular Function
GO:0004576 oligosaccharyl transferase activity
GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043686 co-translational protein modification
GO:0043687 post-translational protein modification
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0008250 oligosaccharyltransferase complex
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6s7o, PDBe:6s7o, PDBj:6s7o
PDBsum6s7o
PubMed31831667
UniProtP46977|STT3A_HUMAN Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Gene Name=STT3A)

[Back to BioLiP]