Structure of PDB 6s4u Chain A

Receptor sequence
>6s4uA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPQSRDARQQRFAHFTE
LAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHE
TECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALL
IAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLM
KLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV
3D structure
PDB6s4u Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands.
ChainA
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KVK A F271 L274 A275 S278 M312 E315 T316 R319 F329 L330 H435 F48 L51 A52 S55 M89 E92 T93 R96 F106 L107 H212 PDBbind-CN: -logKd/Ki=7.76,Ki=17.4nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6s4u, PDBe:6s4u, PDBj:6s4u
PDBsum6s4u
PubMed31799433
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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