Structure of PDB 6s4t Chain A

Receptor sequence
>6s4tA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTAAQELMIQQLVAAQLQCNKRSFSKVTPWPLGADPQSRDARQQRFAHF
TELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYN
HETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYA
LLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDV
3D structure
PDB6s4t Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KVB A F271 L274 S278 T316 R319 F329 L330 F340 I353 H435 L449 W457 F50 L53 S57 T95 R98 F108 L109 F119 I132 H214 L228 W236 MOAD: Ki=0.00000079M
PDBbind-CN: -logKd/Ki=7.95,Ki=11.2nM
BindingDB: EC50=90nM,IC50=2000nM
BS02 KVB A V279 V283 K287 Q300 I301 L304 K305 T308 V58 V62 K66 Q79 I80 L83 K84 T87 MOAD: Ki=0.00000079M
PDBbind-CN: -logKd/Ki=7.95,Ki=11.2nM
BindingDB: EC50=90nM,IC50=2000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6s4t, PDBe:6s4t, PDBj:6s4t
PDBsum6s4t
PubMed31799433
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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