Structure of PDB 6s3h Chain A

Receptor sequence

>6s3hA (length=422) Species: 751945 (Thermus oshimai JL-2) [Search protein sequence]

GLSSEQQRAFLAVTQTPHPAHLITGPAGTGKTTLLYALQEFYKGRAVTLA
PTGTAALQARGQTVHSFFRFPARLLRYRHPEDIRPPGPHSPLRKAIEQME
VLILDEVGMVRVDLLEAMDWALRKTRKRLEEPFGGVKVLLLGDTRQLEPV
VPGGEEALYIARTWGGPFFFQAHVWEEVALRVHRLWESQRQREDPLFAEL
LKRLRQGDPQALETLNRAAVRPDGGEEPGTLILTPRRKEADALNLKRLEA
LPGKPLEYQAQVKGEFAETDFPTEAALTLKKGAQVILLRNDPLGEYFNGD
LGWVEDLEAEALAVRLKRNGRRVVIRPFVWEKIVVVGTFRQVPVRLAWAL
TVHKAQGLTLDKVHLELGRGLFAHGQLYVALTRVRRLQDLSLSRPIAPTE
LLWRPEVEVFETRIQEGIWQKS

3D structure

PDB

6s3h Structural and functional studies of SF1B Pif1 from Thermus oshimai reveal dimerization-induced helicase inhibition.

Chain

Resolution

2.06 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	P117 T118 T129 H131 R135 A138 V216 P218 R302 R303 F332 P338 W396 E397 K398 T430 H432 K433 F451	P51 T52 T63 H65 R69 A72 V150 P152 R236 R237 F266 P272 W330 E331 K332 T351 H353 K354 F372
BS02	ADP	A	Q72 G94 G96 K97 T98 T99 Q255 R256 R258	Q6 G28 G30 K31 T32 T33 Q189 R190 R192
BS03	ALF	A	A93 G94 K97 E172 Q212 R256 G436 R462	A27 G28 K31 E106 Q146 R190 G357 R383

Gene Ontology

	Molecular Function
GO:0003678	DNA helicase activity
GO:0016887	ATP hydrolysis activity

	Biological Process
GO:0000723	telomere maintenance
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6s3h, PDBe:6s3h, PDBj:6s3h
PDBsum	6s3h
PubMed	33784404
UniProt	K7RJ88

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