Structure of PDB 6s1z Chain A

Receptor sequence
>6s1zA (length=585) Species: 7165 (Anopheles gambiae) [Search protein sequence]
PSETEISQIVEWIEQRYQQTKAHQTLAAWEYGSNLTEFNLSKKTKAAADF
AEVAKAVAEELATLKRRIKKLAKLGYAALPADQFKELLGAIASMESNYAK
AKFCAYGDATKCDLSLDPELTEIFANHREPEELKYYWVQWYNATGAPVRE
SFQKYVELNRQAALRNNFSSGAAVWLNEYDDSTFEQQVDDVIEQIRPLYE
QLHAYVRYKLRQKYGDKLVSPTGPIPMHLLGNLWAQTWDNIADFTTPFPE
KKLLDVTDEMIRQGYTPIKMFQMGDDFFTSLNMTKLPQTFWDKSILEKPT
DGRDLVCHASAWDFFAIDDVRIKQCTRVNMREFFVVHHELGHIQYYLQYQ
HQPVEFRGGANPGFHEAVGDVLSLSVSTPKHLKKVGLLKDYEEDEQVKIN
QFYRAGVTKLVFLPFAYTLDKYRWGVFRGDIKPREYNCKFWEMRSRYSGV
EPPVVRTEQDFDPPAKYHVSADVEYLRYFVSYVIQFQFHRAACALAGEYV
KGDPEKTLNNCDIYQSTAAGNQLKEMLALGSSKPWPDAMEVLTGERKMSA
DAILEYFDPLYQWLLEENKRLGAHVGWTDSQKCVS
3D structure
PDB6s1z Crystal structures of angiotensin-converting enzyme from Anopheles gambiae in its native form and with a bound inhibitor.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H353 A354 H383 E384 H387 E411 H513 Y523
Catalytic site (residue number reindexed from 1) H308 A309 H338 E339 H342 E366 H468 Y478
Enzyme Commision number 3.4.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KS8 A Q281 H353 A354 H383 E384 K511 Y512 H513 Y520 Y523 Y527 Q236 H308 A309 H338 E339 K466 Y467 H468 Y475 Y478 Y482 MOAD: ic50=1.5nM
BS02 ZN A H383 H387 E411 H338 H342 E366
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6s1z, PDBe:6s1z, PDBj:6s1z
PDBsum6s1z
PubMed31682720
UniProtA0NFU8

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