Structure of PDB 6s1s Chain A

Receptor sequence
>6s1sA (length=367) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
APADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGR
RVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFD
GISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYS
NPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQ
GYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQA
LDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARL
PAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVK
IAYAILSGLEQQGKVPL
3D structure
PDB6s1s Phenylboronic Acids Probing Molecular Recognition against Class A and Class C beta-lactamases.
ChainA
Resolution1.78 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S64 K67 Y151 E273 K316 S319
Catalytic site (residue number reindexed from 1) S62 K65 Y149 E271 K314 S317
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KRT A S64 Q120 Y151 Y223 S319 T320 S62 Q118 Y149 Y221 S317 T318 PDBbind-CN: -logKd/Ki=5.84,Ki=1.45uM
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6s1s, PDBe:6s1s, PDBj:6s1s
PDBsum6s1s
PubMed31574990
UniProtQ541D8

[Back to BioLiP]