Structure of PDB 6s1f Chain A

Receptor sequence
>6s1fA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTP
LLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLN
ELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILL
DNEFHVKIADFGLSKWRGTIIYMPPENYEPGQKKHDIYSYAVITWEVLSR
KQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQ
NPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQS
3D structure
PDB6s1f Design of 3,5-diaryl-2-aminopyridines as receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors
ChainA
Resolution3.11 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 Q150 N151 D164
Catalytic site (residue number reindexed from 1) D142 Q146 N147 D160
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KRE A V32 A45 K47 T95 M98 L153 D164 V28 A41 K43 T91 M94 L149 D160
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6s1f, PDBe:6s1f, PDBj:6s1f
PDBsum6s1f
PubMed
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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