Structure of PDB 6s16 Chain A

Receptor sequence
>6s16A (length=158) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
HMVVAGIDPGITHLGLGVVAVELKARLLHGEVVKTSPQEPAKERVGRIHA
RVLEVLHRFRPEAVAVEEQFFYRQNELAYKVGWALGAVLVAAFEAGVPVY
AYGPMQVKQALAGKEEVALMVRGILGLKEAPRPSHLADALAIALTHAFYA
RMGTAKPL
3D structure
PDB6s16 RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution.
ChainA
Resolution3.409 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.10: crossover junction endodeoxyribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A G9 I10 T11 R47 Q72 F73 F74 R76 L80 G10 I11 T12 R44 Q69 F70 F71 R73 L77
BS02 dna A R76 Q77 R73 Q74
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0008821 crossover junction DNA endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
Cellular Component
GO:0005737 cytoplasm
GO:0048476 Holliday junction resolvase complex

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Cellular Component
External links
PDB RCSB:6s16, PDBe:6s16, PDBj:6s16
PDBsum6s16
PubMed31506434
UniProtQ5SJC4|RUVC_THET8 Crossover junction endodeoxyribonuclease RuvC (Gene Name=ruvC)

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