Structure of PDB 6rz6 Chain A

Receptor sequence
>6rz6A (length=365) Species: 562,9606 [Search protein sequence]
RNCTIENFKREFFPIVYLIIFFVGVLGNGLSIYVFLQPYKKSTSVNVFML
NLAISNLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYF
LTVLSVVRYLAMVHPFRVTSIRSAWILCGIIWILIMASSIMLLDSEQNGS
VTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEA
DLEDNWETLNDNLKVIEKAAAQVKDALTKMRAAALDAQMKDFRHGFDILV
GQIDDALKLVKEAQAAAEQLKTTRNAYIQKYLVSHRKALTTIIITLIIFF
LCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYF
AGENFKDRLKSALRK
3D structure
PDB6rz6 Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.
ChainA
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KNW A K37 Y119 Y123 S170 M201 N202 R267 L271 H284 K9 Y91 Y95 S139 M168 N169 R310 L314 H327 PDBbind-CN: -logKd/Ki=8.54,IC50=2.9nM
BS02 CLR A S218 Y221 S185 Y188
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004974 leukotriene receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:6rz6, PDBe:6rz6, PDBj:6rz6
PDBsum6rz6
PubMed31811124
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
Q9NS75

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