Structure of PDB 6rxq Chain A

Receptor sequence

>6rxqA (length=224) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAG
NTNVIHMHGELLKVRCSQSGQALDWTGDVTPPLRPHVVWFGEMPLGMDEI
YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF
AEKYYGPASQVVPEFVEKLLKGLK

3D structure

PDB

6rxq Evolved, Selective Erasers of Distinct Lysine Acylations.

Chain

Resolution

1.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.286: protein acetyllysine N-acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	H147 V188 F190 G191 E192 M193 Y201 H218 V219 Y220	H108 V138 F140 G141 E142 M143 Y151 H168 V169 Y170
BS02	peptide	A	E73 E79 R83 G191	E34 E40 R44 G141
BS03	KMQ	A	G48 A49 G50 A53 E54 F60 Q129 H147 V188 G214 T215 S216 V219 N240 L241 P257 A258	G9 A10 G11 A14 E15 F21 Q90 H108 V138 G164 T165 S166 V169 N190 L191 P207 A208

Gene Ontology

	Molecular Function
GO:0036054	protein-malonyllysine demalonylase activity
GO:0036055	protein-succinyllysine desuccinylase activity
GO:0070403	NAD+ binding

View graph for
Molecular Function

External links

PDB	RCSB:6rxq, PDBe:6rxq, PDBj:6rxq
PDBsum	6rxq
PubMed	32187803
UniProt	P75960\|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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