Structure of PDB 6rwm Chain A

Receptor sequence
>6rwmA (length=270) Species: 11723 (Simian immunodeficiency virus) [Search protein sequence]
GFLDGIEKAQEEHEKYHNNWRAMAEDFQIPQVVAKEIVAQCPKCQVKGEA
MHGQVDASPKTWQMDCTHLEGKVIIVAVHVASGYIEAEVLPAETGKETAH
FLLKLAARWPVKHLHTDNGDNFTSSAVQAVCWWAQIEHTFGVPYNPQSQG
VVESMNHQLKTIITQIRDQAEKIETAVQMAVLIHNFKRKGGIGGYSAGER
IIDIIASDLQTTKLQNQISKIQNFRVYFREGRDQQWKGPATLIWKGEGAV
VIQDGQDLKVVPRRKCKIIK
3D structure
PDB6rwm Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
ChainA
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E152 H156 E153 H157
BS02 dna A G52 Q53 V54 V141 Q146 S147 S153 Q157 G53 Q54 V55 V142 Q147 S148 S154 Q158
BS03 dna A Q30 A49 H51 Q31 A50 H52
BS04 dna A K46 G47 K47 G48
BS05 ZN A H12 H16 C40 H13 H17 C41
BS06 MG A D64 D116 D65 D117
BS07 MG A D64 E152 D65 E153
BS08 KLQ A D64 D116 P145 Q146 E152 D65 D117 P146 Q147 E153
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:6rwm, PDBe:6rwm, PDBj:6rwm
PDBsum6rwm
PubMed32001525
UniProtE1ANT8

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