Structure of PDB 6rv3 Chain A

Receptor sequence

>6rv3A (length=258) Species: 9606 (Homo sapiens)

MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRA
RYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAA
PSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGAD
VSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFG
DYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAED
EKRDAENL

3D structure

• PDB: 6rv3 A lower X-gate in TASK channels traps inhibitors within the vestibule.
• Chain: A
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	K	A	I94 G95 Y96 I200 G201 F202	I94 G95 Y96 I197 G198 F199
BS02	K	A	T93 I94 G95 T199 I200 G201	T93 I94 G95 T196 I197 G198
BS03	K	A	T93 T199	T93 T196
BS04	Y01	A	R7 F238 F246	R7 F235 F243
BS05	Y01	A	F80 A81 F84 Q215 F225	F80 A81 F84 Q212 F222
BS06	K	A	G95 Y96 G97 G201 F202 G203	G95 Y96 G97 G198 F199 G200
BS07	KKQ	A	T92 L122 F125 L197 T199 L232 L239	T92 L122 F125 L194 T196 L229 L236	BindingDB: IC50=172nM
BS08	Y01	A	L115 P119	L115 P119

Gene Ontology

Molecular Function

• GO:0005252 open rectifier potassium channel activity
• GO:0005267 potassium channel activity

Biological Process

• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6rv3, PDBe:6rv3, PDBj:6rv3
• PDBsum: 6rv3
• PubMed: 32499642
• UniProt: O14649|KCNK3_HUMAN Potassium channel subfamily K member 3 (Gene Name=KCNK3)