Structure of PDB 6rv2 Chain A

Receptor sequence
>6rv2A (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRA
RYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAA
PSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGAD
VSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFG
DYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAED
EKRD
3D structure
PDB6rv2 A lower X-gate in TASK channels traps inhibitors within the vestibule.
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K A I94 G95 Y96 I200 G201 F202 I94 G95 Y96 I197 G198 F199
BS02 K A T93 I94 T199 I200 G201 T93 I94 T196 I197 G198
BS03 K A T93 T199 T93 T196
BS04 Y01 A R3 L11 F246 R3 L11 F243
BS05 Y01 A R79 F80 A81 F84 F225 R79 F80 A81 F84 F222
BS06 K A G95 Y96 G97 G201 F202 G203 G95 Y96 G97 G198 F199 G200
Gene Ontology
Molecular Function
GO:0005252 open rectifier potassium channel activity
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6rv2, PDBe:6rv2, PDBj:6rv2
PDBsum6rv2
PubMed32499642
UniProtO14649|KCNK3_HUMAN Potassium channel subfamily K member 3 (Gene Name=KCNK3)

[Back to BioLiP]