Structure of PDB 6rum Chain A

Receptor sequence
>6rumA (length=276) Species: 9844 (Lama glama) [Search protein sequence]
QVQLVESGGALVQPGGSLRLSCAASGFPVNRYSMRWYRQAPGKEREWVAG
MSSAGDRSSYEDSVKGRFTISRDDARNTVYLQMNSLKPEDTAVYYCNVNV
GLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRV
TWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD
THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERRGGGMISLIAALAV
DRVIGMENAMPWNFEYWGQGTQVTVS
3D structure
PDB6rum Chemogenetic Control of Nanobodies.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G97 D101 L102 F105 L128 I165 T187
Catalytic site (residue number reindexed from 1) G101 D105 L106 F109 L132 I169 T191
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TOP A D101 F105 I124 I168 I243 A244 M258 D105 F109 I128 I172 I245 A246 M260 BindingDB: IC50=10nM,Ki=3.0nM
BS02 NDP A G117 R118 H119 T120 L136 S137 S138 K150 I168 G170 G171 R172 V173 Q176 A244 A245 I252 N256 A257 M258 G121 R122 H123 T124 L140 S141 S142 K154 I172 G174 G175 R176 V177 Q180 A246 A247 I254 N258 A259 M260
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
Biological Process
GO:0046654 tetrahydrofolate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6rum, PDBe:6rum, PDBj:6rum
PDBsum6rum
PubMed32066961
UniProtP0ABQ4|DYR_ECOLI Dihydrofolate reductase (Gene Name=folA)

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