Structure of PDB 6ru7 Chain A

Receptor sequence
>6ru7A (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIE
SKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSL
KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGL
AKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYV
LMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYL
NFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB6ru7 p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
ChainA
Resolution2.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R127 D128 K130 L152 A153 K171 T174 G175 T176 R178 Q214 A219 K221 Y225 R125 D126 K128 L150 A151 K169 T172 G173 T174 R176 Q212 A217 K219 Y223
BS02 ADP A G18 I23 A36 K38 E52 Y56 M82 L85 I148 D149 G16 I21 A34 K36 E50 Y54 M80 L83 I146 D147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ru7, PDBe:6ru7, PDBj:6ru7
PDBsum6ru7
PubMed32719556
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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