Structure of PDB 6ru6 Chain A

Receptor sequence
>6ru6A (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
LRVGNRYRLGRKIGSDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIY
KMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVL
LLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKY
RDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYF
NLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCR
SLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB6ru6 p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
ChainA
Resolution2.05 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D128 K130 G175 T176 A177 R178 Q214 D122 K124 G169 T170 A171 R172 Q208
BS02 ACP A S17 I23 A36 K38 M82 L85 L135 D149 S15 I17 A30 K32 M76 L79 L129 D143
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ru6, PDBe:6ru6, PDBj:6ru6
PDBsum6ru6
PubMed32719556
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

[Back to BioLiP]