Structure of PDB 6rsk Chain A

Receptor sequence

>6rskA (length=108) Species: 559292 (Saccharomyces cerevisiae S288C)

AEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEG
YSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLI
TYLKKATE

3D structure

• PDB: 6rsk Tuning Protein Frameworks via Auxiliary Supramolecular Interactions.
• Chain: A
• Resolution: 2.31 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEC	A	R13 C14 C17 H18 V28 G29 P30 I35 S40 G41 Y46 Y48 T49 N52 W59 M64 Y67 L68 T78 M80 F82 L94	R18 C19 C22 H23 V33 G34 P35 I40 S45 G46 Y51 Y53 T54 N57 W64 M69 Y72 L73 T83 M85 F87 L99
BS02	EVB	A	K11 L15 Q16 P25 K27	K16 L20 Q21 P30 K32
BS03	EVB	A	A-1 A3 K4 T96 Y97 K100	A5 A8 K9 T101 Y102 K105
BS04	EVB	A	N70 K72 K73 K79 M80 A81 F82 G83	N75 K77 K78 K84 M85 A86 F87 G88

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding
• GO:1901612 cardiolipin binding

Biological Process

• GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
• GO:0006123 mitochondrial electron transport, cytochrome c to oxygen

Cellular Component

• GO:0005739 mitochondrion
• GO:0005758 mitochondrial intermembrane space

External links

• PDB: RCSB:6rsk, PDBe:6rsk, PDBj:6rsk
• PDBsum: 6rsk
• PubMed: 31490058
• UniProt: P00044|CYC1_YEAST Cytochrome c isoform 1 (Gene Name=CYC1)