Structure of PDB 6rse Chain A

Receptor sequence
>6rseA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPES
GGNHIADLKKEIEILRNLYHENIVKYKGICTEGIKLIMEFLPSGSLKEYL
PKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVK
IGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFG
VTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPP
NCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
3D structure
PDB6rse Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1003 A1005 R1007 N1008 D1021
Catalytic site (residue number reindexed from 1) D135 A137 R139 N140 D153
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KHH A L881 G882 E883 G887 K888 V889 A906 K908 F958 L959 G962 R1007 N1008 L1010 G1020 D1021 L17 G18 E19 G23 K24 V25 A42 K44 F90 L91 G94 R139 N140 L142 G152 D153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6rse, PDBe:6rse, PDBj:6rse
PDBsum6rse
PubMed
UniProtP23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)

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