Structure of PDB 6rr7 Chain A

Receptor sequence
>6rr7A (length=716) Species: 384505 (Influenza A virus (A/nt/60/1968(H3N2))) [Search protein sequence]
MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSD
FHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGA
EKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSF
TGEEMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEET
IEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGYIEGKLSQMS
KEVNAKIEPFLKTTPRPIRLPDGPPCFQRSKFLLMDALKLSIEDPSHEGE
GIPLYDAIKCMRTFFGWKEPYIVKPHEKGINPNYLLSWKQVLAELQDIEN
EEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDVSDLKQYDSDEPEL
RSLSSWIQNEFNKACELTDSTWIELDEIGEDVAPIEYIASMRRNYFTAEV
SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL
YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL
RSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES
SVKEKDMTKEFFENKSETWPIGESPKGVEDGSIGKVCRTLLAKSVFNSLY
ASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLEGLYEAIEECLINDPWV
LLNASWFNSFLTHALR
3D structure
PDB6rr7 Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
ChainA
Resolution3.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A M477 H510 L511 R512 M477 H510 L511 R512
BS02 rna A R279 H326 G371 A375 Y393 D394 S395 E397 P398 H510 D516 V517 K539 N568 R279 H326 G371 A375 Y393 D394 S395 E397 P398 H510 D516 V517 K539 N568
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rr7, PDBe:6rr7, PDBj:6rr7
PDBsum6rr7
PubMed31485076
UniProtP03434|PA_I68A6 Polymerase acidic protein (Gene Name=PA)

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