Structure of PDB 6roy Chain A

Receptor sequence
>6royA (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
NC
3D structure
PDB6roy Molecular mechanism of SHP2 activation by PD-1 stimulation.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R32 S34 K35 S36 T42 H53 I54 K55 L65 G67 G68 Q87 K89 E90 K91 R30 S32 K33 S34 T40 H51 I52 K53 L63 G65 G66 Q85 K87 E88 K89
External links
PDB RCSB:6roy, PDBe:6roy, PDBj:6roy
PDBsum6roy
PubMed32064351
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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