Structure of PDB 6ro1 Chain A

Receptor sequence
>6ro1A (length=919) Species: 9606 (Homo sapiens) [Search protein sequence]
LADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILD
AFQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPI
KALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSE
VMREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQ
FAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFRED
NFNTAMQVLRDAGDLAKKGPSNVFKIVKMIMERNFQPVIIFSFSKKDCEA
YALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRG
IGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNA
RKFDGKDFRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQL
LKGSADPLNSAFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGV
VEKVKNSEEQYNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCL
PFLQPGRLVKVKNEGDDFGWGVVVNFSKKSLYVVEVLLRCAAKPAKPDEK
GEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDG
IPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCE
KKAQIAIDIKSAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMK
GRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPK
LTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTW
ATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKF
AEGITKIKRDIVFAASLYL
3D structure
PDB6ro1 The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
ChainA
Resolution3.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A P652 F653 Q655 R658 S741 V742 R743 Y745 V766 P551 F552 Q554 R557 S618 V619 R620 Y622 V643
BS02 ADP A F138 I139 S164 G166 K167 T168 R527 F47 I48 S73 G75 K76 T77 R426
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0000460 maturation of 5.8S rRNA
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0006974 DNA damage response
GO:0008380 RNA splicing
GO:0016076 snRNA catabolic process
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0031499 TRAMP complex
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ro1, PDBe:6ro1, PDBj:6ro1
PDBsum6ro1
PubMed31358741
UniProtP42285|MTREX_HUMAN Exosome RNA helicase MTR4 (Gene Name=MTREX)

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