Structure of PDB 6rnu Chain A

Receptor sequence
>6rnuA (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
SQSNRELVVDFLSYKLSQKGYSWSQFSESEAVKQALREAGDEFELRYRRA
FSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVES
VDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
3D structure
PDB6rnu Discovery and optimization of covalent Bcl-xL antagonists.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KBH A F97 A104 F105 L130 R132 D133 R139 F43 A50 F51 L76 R78 D79 R85 PDBbind-CN: -logKd/Ki=4.00,IC50>99.2uM
BindingDB: EC50=>31500nM,IC50=>99200nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6rnu, PDBe:6rnu, PDBj:6rnu
PDBsum6rnu
PubMed31606346
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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