Structure of PDB 6rna Chain A

Receptor sequence
>6rnaA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGSGTVSSARHADWRVQVAVKHLLDSERK
DVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKT
EYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVK
IADFGLSKWRMGGTIIYMPPENYSIKHDIYSYAVITWEVLSRKQPFEDVT
NPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSF
LKCLIELEPVLRTFEEITFLEAVIQLK
3D structure
PDB6rna Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
ChainA
Resolution2.62 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 Q150 N151 D164
Catalytic site (residue number reindexed from 1) D135 Q139 N140 D153
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KA2 A L24 S25 V32 A45 K47 E66 L79 T95 Y97 M98 G101 E105 L153 D164 L20 S21 V27 A40 K42 E55 L68 T84 Y86 M87 G90 E94 L142 D153 PDBbind-CN: -logKd/Ki=8.30,IC50=5nM
BindingDB: IC50=0.002000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6rna, PDBe:6rna, PDBj:6rna
PDBsum6rna
PubMed31265286
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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