Structure of PDB 6rln Chain A

Receptor sequence
>6rlnA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
NVIKMKSSDFLEKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMM
NRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGR
IILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSK
LNNEEHNELGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPY
ENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTF
PGIEEKFRPFYLSQLE
3D structure
PDB6rln Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
ChainA
Resolution2.87 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D121 K123 E125 N126 D139 T161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K8K A V31 M44 K45 V76 L90 M92 H136 A155 D156 L157 S161 F162 V14 M27 K28 V59 L73 M75 H119 A138 D139 L140 S144 F145 PDBbind-CN: -logKd/Ki=8.20,IC50=6.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6rln, PDBe:6rln, PDBj:6rln
PDBsum6rln
PubMed31223438
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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