Structure of PDB 6rj6 Chain A

Receptor sequence
>6rj6A (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
NGSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGI
LGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLC
DFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQ
SGQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQSRCGEEIA
VQFV
3D structure
PDB6rj6 Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) InhibitorBI-4924Disrupts Serine Biosynthesis.
ChainA
Resolution1.984 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.37: malate dehydrogenase.
1.1.1.399: 2-oxoglutarate reductase.
1.1.1.95: phosphoglycerate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K5K A G151 R154 I155 Y173 D174 P175 I176 I177 H205 T206 P207 T212 G52 R55 I56 Y74 D75 P76 I77 I78 H106 T107 P108 T113 MOAD: ic50=2nM
PDBbind-CN: -logKd/Ki=8.52,IC50=3nM
BindingDB: IC50=3.0nM
Gene Ontology
Molecular Function
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:6rj6, PDBe:6rj6, PDBj:6rj6
PDBsum6rj6
PubMed31365252
UniProtO43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase (Gene Name=PHGDH)

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