Structure of PDB 6rfn Chain A

Receptor sequence
>6rfnA (length=333) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
VTAITKVEREAVLVCELPSFDVTDVEFDLFRARESTDKPLDVAAAIAYRL
LLGSGLPQKFGCSDEVLLNFILQCRKKYRNVPYHNFYHVVDVCQTIHTFL
YRGNVYEKLTELECFVLLITALVHDLDHMGLNNSFYLKTESPLGILSSAS
GNTSVLEVHHCNLAVEILSDPESDVFDGLEGAERTLAFRSMIDCVLATDM
AKHGSALEAFLASAADQSSDEAAFHRMTMEIILKAGDISNVTKPFDISRQ
WAMAVTEEFYRQGDMEKERGVEVLPMFDRSKNMELAKGQIGFIDFVAAPF
FQKIVDACLQGMQWTVDRIKSNRAQWERVLETR
3D structure
PDB6rfn Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H673 H709 D710 D822 H88 H124 D125 D237
BS02 K3W A M785 D822 N825 M861 G873 Q874 F877 M200 D237 N240 M276 G288 Q289 F292 MOAD: Ki=0.00000079M
PDBbind-CN: -logKd/Ki=6.70,Ki=199.5nM
BindingDB: Ki=200nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6rfn, PDBe:6rfn, PDBj:6rfn
PDBsum6rfn
PubMed31378593
UniProtQ8WQX9

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