Structure of PDB 6ra7 Chain A

Receptor sequence
>6ra7A (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDE
EEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGS
VTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLT
ENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDF
KSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKF
QSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKK
RG
3D structure
PDB6ra7 Tool inhibitors and assays to interrogate the biology of the TRAF2 and NCK interacting kinase
ChainA
Resolution1.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D153 K155 Q157 N158 D171 R180 T191
Catalytic site (residue number reindexed from 1) D141 K143 Q145 N146 D159 R168 T179
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S77 H78 H79 I82 T84 S65 H66 H67 I70 T72
BS02 JWK A V31 Y36 A52 K54 M105 F107 C108 L160 D171 V19 Y24 A40 K42 M93 F95 C96 L148 D159 BindingDB: IC50=126nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ra7, PDBe:6ra7, PDBj:6ra7
PDBsum6ra7
PubMed
UniProtQ9UKE5|TNIK_HUMAN TRAF2 and NCK-interacting protein kinase (Gene Name=TNIK)

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