Structure of PDB 6ra4 Chain A

Receptor sequence
>6ra4A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
PTAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEIT
HCGQMKRKYRVCNVTRRPASHQTFPLTVECTVAQYFKDRHKLVLRYPHLP
CLQVGQEQKHTYLPLEVCNIVAGQRCI
3D structure
PDB6ra4 How to Computationally Stack the Deck for Hit-to-Lead Generation: In Silico Molecular Interaction Energy Profiling for de Novo siRNA Guide Strand Surrogate Selection.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.n2: argonaute-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A K258 H263 M267 R269 R272 F286 L288 Y303 H308 K327 H328 T329 Y330 K46 H51 M55 R57 R60 F74 L76 Y85 H90 K109 H110 T111 Y112
BS02 rna A Q266 K268 Q54 K56
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6ra4, PDBe:6ra4, PDBj:6ra4
PDBsum6ra4
PubMed31021613
UniProtQ9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)

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