Structure of PDB 6r81 Chain A

Receptor sequence

>6r81A (length=572) Species: 1423 (Bacillus subtilis)

KSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSLLIPLLTKQLVDGFS
MSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLRELLWKKLI
KLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTI
LFIMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQ
ILPEIRLVKASNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVL
MAALVAVIGYGTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERM
IEILAEEEEDTVTGKQIENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAG
KVTAIVGPSGGGKTTLFKLLERFYSPTAGTIRLGDEPVDTYSLESWREHI
GYVSQESPLMSGTIRENICYGLERDVTDAEIEKAAEMAYALNFIKELPNQ
FDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDAATSSLDSQSEKSV
QQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMASH
GLYRDFAEQQLKMNADLENKAG

3D structure

• PDB: 6r81 Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
• Chain: A
• Resolution: 3.9 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	Y350 S376 G377 G378 K380 T381 T382 Q422	Y333 S359 G360 G361 K363 T364 T365 Q405
BS02	ATP	A	I477 M478 L479 S480 G482	I460 M461 L462 S463 G465
BS03	MG	A	T381 Q422 D503	T364 Q405 D486

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0034040 ATPase-coupled lipid transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006869 lipid transport
• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6r81, PDBe:6r81, PDBj:6r81
• PDBsum: 6r81
• PubMed: 35080979
• UniProt: O06967|BMRA_BACSU Multidrug resistance ABC transporter ATP-binding/permease protein BmrA (Gene Name=bmrA)