Structure of PDB 6r72 Chain A

Receptor sequence

>6r72A (length=571) Species: 1423 (Bacillus subtilis)

SKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSLLIPLLTKQLVDGFSM
SNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLRELLWKKLIK
LPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTIL
FIMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQI
LPEIRLVKASNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLM
AALVAVIGYGTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMI
EILAEEEEDTVTGKQIENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGK
VTAIVGPSGGGKTTLFKLLERFYSPTAGTIRLGDEPVDTYSLESWREHIG
YVSQESPLMSGTIRENICYGLERDVTDAEIEKAAEMAYALNFIKELPNQF
DTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDAATSSLDSQSEKSVQ
QALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMASHG
LYRDFAEQQLKMNADLENKAG

3D structure

• PDB: 6r72 Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
• Chain: A
• Resolution: 3.95 Å

Enzymatic activity

• Enzyme Commision number: 7.6.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	D116 Y350 S376 G377 G378 K380 T381 T382 K385 Q422	D107 Y332 S358 G359 G360 K362 T363 T364 K367 Q404
BS02	MG	A	T381 Q422	T363 Q404
BS03	ATP	A	M478 S480 G481 G482	M460 S462 G463 G464

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0034040 ATPase-coupled lipid transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006869 lipid transport
• GO:0046677 response to antibiotic
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6r72, PDBe:6r72, PDBj:6r72
• PDBsum: 6r72
• PubMed: 35080979
• UniProt: O06967|BMRA_BACSU Multidrug resistance ABC transporter ATP-binding/permease protein BmrA (Gene Name=bmrA)