Structure of PDB 6r5c Chain A

Receptor sequence
>6r5cA (length=193) Species: 1496 (Clostridioides difficile) [Search protein sequence]
STTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKYLNALKQNNL
KIKLLSGKLTDEKEYAYLKGVVPKGFEGTGKTWDDVPGLGGSTVALRIGF
SNKGKGHDAINLELHATAHAIDHIVLNDISKSAQFKQIFAKEGRSLGNVN
FLGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK
3D structure
PDB6r5c Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
ChainA
Resolution1.881 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.89: Pro-Pro endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A P100 K101 F103 W110 V113 L116 G117 G118 S119 H134 D135 L139 H142 H146 H150 N175 F178 E185 P73 K74 F76 W83 V86 L89 G90 G91 S92 H107 D108 L112 H115 H119 H123 N148 F151 E158
BS02 ZN A H142 H146 E185 H115 H119 E158
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r5c, PDBe:6r5c, PDBj:6r5c
PDBsum6r5c
PubMed31182482
UniProtQ183R7|PPEP1_CLOD6 Pro-Pro endopeptidase (Gene Name=zmp1)

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