Structure of PDB 6r4z Chain A

Receptor sequence
>6r4zA (length=198) Species: 1496 (Clostridioides difficile) [Search protein sequence]
GSHMDSTTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKYLNAL
KQNNLKIKLLSGKLTDEKEYAYLKGVVPKGWEGTGKTWDDVPGLGGSTVA
LRIGFSNKGKGHDAINLELHATAHAIDHIVLNDISKSAQFKQIFAKEGRS
LGNVNFLGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK
3D structure
PDB6r4z Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
ChainA
Resolution1.052 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.24.89: Pro-Pro endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K101 W110 L116 G117 S119 H146 H150 E185 K79 W88 L94 G95 S97 H124 H128 E163
BS02 ZN A H142 H146 E185 H120 H124 E163
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6r4z, PDBe:6r4z, PDBj:6r4z
PDBsum6r4z
PubMed31182482
UniProtQ183R7|PPEP1_CLOD6 Pro-Pro endopeptidase (Gene Name=zmp1)

[Back to BioLiP]