Structure of PDB 6r4y Chain A

Receptor sequence
>6r4yA (length=193) Species: 1496 (Clostridioides difficile) [Search protein sequence]
STTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKYLNALKQNNL
KIKLLSGKLTDEKEYAYLKGVVPKGWEGTGKTWDDVPGLGGSTVALRIGF
SNKGKGHDAINLELHATAHAIDHIVLNDISKSAQFKQIFAKEGRSLGNVN
FLGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK
3D structure
PDB6r4y Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
ChainA
Resolution1.452 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.89: Pro-Pro endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K101 W110 L116 G117 G118 S119 H146 H150 E185 K74 W83 L89 G90 G91 S92 H119 H123 E158
BS02 ZN A H142 H146 E185 H115 H119 E158
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r4y, PDBe:6r4y, PDBj:6r4y
PDBsum6r4y
PubMed31182482
UniProtQ183R7|PPEP1_CLOD6 Pro-Pro endopeptidase (Gene Name=zmp1)

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