Structure of PDB 6r4x Chain A

Receptor sequence
>6r4xA (length=195) Species: 1496 (Clostridioides difficile) [Search protein sequence]
MDSTTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKYLNALKQN
NLKIKLLSGKLTDEKEYAYLKGVVPKGWEGTGKTWDDVPGLGGSTVALRI
GFSNKGKGHDAINLELHATAHAIDHIVLNDISKSAQFKQIFAKEGRSLGN
VNFLGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK
3D structure
PDB6r4x Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
ChainA
Resolution1.831 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.89: Pro-Pro endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A P100 K101 W103 W110 L116 G117 G118 S119 H134 D135 A136 H142 H146 H150 F178 P75 K76 W78 W85 L91 G92 G93 S94 H109 D110 A111 H117 H121 H125 F153
BS02 ZN A H142 H146 E185 H117 H121 E160
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r4x, PDBe:6r4x, PDBj:6r4x
PDBsum6r4x
PubMed31182482
UniProtQ183R7|PPEP1_CLOD6 Pro-Pro endopeptidase (Gene Name=zmp1)

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