Structure of PDB 6r4o Chain A

Receptor sequence
>6r4oA (length=841) Species: 9913 (Bos taurus) [Search protein sequence]
SVNLEEACMERCFPQTQRRFRYALFYIGFACLLWSIYFGVHMKSKLIVMV
APALCFLVVCVGFFLFTFTKLYARHYVWTSLVLTLLVFALTLAAQFQVLT
PCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLILGVAYSVLFETFGYHHWE
LLSRALLHLCIHAIGIHLFIMSQVRSRSTFLKVGQSIMHGKDLEVEKALK
ERMIHSVMPRIIADDLMKQGDEESENSVKIAFRPFKMQQIEEVSILFADI
VGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG
CPEPRADHAYCCIEMGLGMIRAIEQFCQEKKEMVNMRVGVHTGTVLCGIL
GMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKV
TELKTYLIAGQFASATFSSLLDVLLSTTVFLILSITCFLRYGAASTPPPP
AALAVFGAALLLEILSLVVSVRMVFFLEDVMTCTKRLLEWIAGWLPRHFI
GAILVSLPALAVYSHVTSEFETNIHSTMFTGSAVLTAVVQYCNFCQLSSW
MRSSLATVVGAGPLLLLLYVSASLIGQEVILVFFLLLLLVWFLNREFEVS
YRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVSQTYSKN
HDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSS
IEKIKTIGATYMAASGLNATQCRDGSHPQEHLQILFEFAKEMMRVVDDFN
NNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVE
CRIQVSEESYRVLSKMGYEFDYRGTVNVKGKGQMKTYLYPK
3D structure
PDB6r4o The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein.
ChainA
Resolution4.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D399 I400 D443 L519 K1233
Catalytic site (residue number reindexed from 1) D249 I250 D293 L369 K829
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ONM A D399 V401 G402 F403 T404 L415 L441 G442 D443 W1188 G1189 D1190 N1193 D249 V251 G252 F253 T254 L265 L291 G292 D293 W784 G785 D786 N789
BS02 FOK A V514 N515 N518 A1113 V364 N365 N368 A709
BS03 MN A D399 I400 V401 D249 I250 V251
Gene Ontology
Molecular Function
GO:0004016 adenylate cyclase activity
GO:0005524 ATP binding
GO:0016829 lyase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006091 generation of precursor metabolites and energy
GO:0006171 cAMP biosynthetic process
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008218 bioluminescence
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r4o, PDBe:6r4o, PDBj:6r4o
PDBsum6r4o
PubMed31023924
UniProtE1BM79

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