Structure of PDB 6r4l Chain A

Receptor sequence

>6r4lA (length=1096) Species: 559292 (Saccharomyces cerevisiae S288C)

ATCAMYGNCGKKSVFGNELPCPVPRSFEPPVLSDETSKLLVEVCGEEWKE
VRYACCTKDQVVALRDNLQKAQPLISSCPACLKNFNNLFCHFTCAADQGR
FVNITKVEKSKEDKDIVAELDVFMNSSWASEFYDSCKNIKFSATNGYAMD
LIGGGAKNYSQFLKFLGDAKPMLGGSPFQINYKYDLANEEKEWQEFNDEV
YACDDAQYKCACSDCQESCPHLKPLKDGVCKVGPLPCFSLSVLIFYTICA
LFAFMWYYLTNFFNGKLANLFTKVGQFSVENPYKILITTVFSIFVFSFII
FQYATLETDPINLWVSKNSEKFKEKEYFDDNFGPFYRTEQIFVVNETGPV
LSYETLHWWFDVENFITEELQSSENIGYQDLCFRPTEDSTCVIESFTQYF
QGALPNKDSWKRELQECGKFPVNCLPTFQQPLKTNLLFSDDDILNAHAFV
VTLLLTNHTQSANRWEERLEEYLLDLKVPEGLRISFNTEISLEKELNNNN
DISTVAISYLMMFLYATWALRRKDGKTRLLLGISGLLIVLASIVCAAGFL
TLFGLKSTLIIAEVIPFLILAIGIDNIFLITHEYDRNCEQKPEYSIDQKI
ISAIGRMSPSILMSLLCQTGCFLIAAFVTMPAVHNFAIYSTVSVIFNGVL
QLTAYVSILSLYEKRSNYKQITSFLKTFYFKMLTQKRLIIIIFSAWFFTS
LVFLPEIQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLT
KRQNQQKICGKFTTCERDSLANVLEQERHRSTITEPLANWLDDYFMFLNP
QNDQCCRLKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEY
LSIWINAPSDPCPLGGRAPYSTALVYNETSVSASVFRTAHHPLRSQKDFI
QAYSDGVRISSSFPELDMFAYSPFYIFFVQYQTLGPLTLKLIGSAIILIF
FISSVFLQNIRSSFLLALVVTMIIVDIGALMALLGISLNAVSLVNLIICV
GLGVEFCVHIVRSFTVVPSETKKDANSRVLYSLNTIGESVIKGITLTKFI
GVCVLAFAQSKIFDVFYFRMWFTLIIVAALHALLFLPALLSLFGGE

3D structure

• PDB: 6r4l Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.
• Chain: A
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ERG	A	F391 Y392 Q396 G800 P801 P986	F335 Y336 Q340 G737 P738 P923

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6r4l, PDBe:6r4l, PDBj:6r4l
• PDBsum: 6r4l
• PubMed: 31543266
• UniProt: Q12200|NPC1_YEAST NPC intracellular sterol transporter 1-related protein 1 (Gene Name=NCR1)